The mineral magnesium is crucial for the body to function properly because magnesium is involved in more than 600 of the body's enzymatic reactions.*

According to World Health Organization statistics, as many as 75 percent of U.S. adults do not meet the U.S. Food and Drug Administration's Recommended Daily Intake of 420 mg of magnesium. Magnesium deficiency can manifest in many ways, such as inefficient blood sugar metabolism, muscle cramps or soreness, eyelid twitching, fatigue, and poor sleep.*

Why is magnesium important?

• Magnesium is essential for the health of the heart and blood vessels, brain, bones, muscles, and lungs, and to support healthy blood sugar*
• Promotes bronchial relaxation*
• It’s an essential mineral for electrical activity of the heart, which supports healthy heart rate and rhythm*
• Helps relax smooth and skeletal muscle*
• Promotes the dilation of blood vessels (vasodilation), which supports normal blood pressure and enhances blood flow*
• Supports insulin sensitivity for healthy blood sugar*
• Is a cofactor for enzymes involved in cellular energy production*

Benefits of Thorne’s Magnesium Bisglycinate:

• Magnesium Bisglycinate is a great-tasting powder that can be mixed with water, juice, or with another powdered supplement.
• The compound magnesium bisglycinate is also called magnesium glycinate; however, because it has two glycine molecules attached, it is more accurately called "bisglycinate" (bis = two). The bisglycinate form has superior absorption because of increased solubility.*
• Decreased laxative effect compared to other magnesium formulations because the bisglycinate form is a true chelate that completely envelopes the magnesium.*
• Glycine is a neurotransmitter that promotes relaxation and stress reduction in the body – making Magnesium Bisglycinate a good choice for pre-bedtime supplementation to support restful sleep.*

Because athletes need to know their supplements are trustworthy, every batch of an NSF Certified for Sport® product is tested for compliance with label claims and to ensure the absence of more than 200 substances banned by many major athletic organizations.

Thorne's Melaton-3 is NSF Certified for Sport®. Thorne offers melatonin in both 3 mg (Melatonin-3) and 5 mg (Melatonin-5) capsules. Melatonin, the primary hormone of the pineal gland, is a powerful "chronobiotic" that helps maintain the body's normal circadian rhythms.* In individuals who have difficulty sleeping or who have altered circadian rhythms because of jet lag or night shift work, melatonin supplementation promotes the resynchronization of this cycle.* Supplementation can also benefit those whose difficulty sleeping is caused by the aging-related decrease in the body's ability to synthesize melatonin from the amino acid tryptophan.* Research indicates melatonin exerts its sleep-promoting efficacy by decreasing the amount of time needed to fall asleep, by promoting the ability to stay asleep, and by enhancing the depth of sleep.*

Melatonin administration from 0.3 mg to 5.0 mg has been shown to exert a sedative-like effect.* When supplemented prior to the onset of the body's normal melatonin secretion, even a low amount of melatonin can promote sleep.* Melatonin apparently enhances the effect of gamma-aminobutyric acid (GABA) via direct interaction with GABA receptors, thus resulting in relaxation.* Thorne's Melaton-3 supplies three mg of melatonin in each capsule, and Melaton-5 supplies 5 mg per capsule and is used when a higher amount of melatonin is desired. Melatonin also has significant antioxidant activity.* Adequate melatonin levels have been reported to be a positive factor in cardiovascular, neuroendocrine, GI, and bone health.*

Because an athlete needs to know that his or her supplements are trustworthy and compliant, every batch of an NSF Certified for Sport® product is tested for compliance with label claims and to ensure the absence of more than 200 substances banned by many major athletic organizations, including stimulants, narcotics, steroids, diuretics, beta-2 agonists, and masking agents.

Gamma-aminobutyric acid (GABA) is a major calming brain chemical or neurotransmitter.* Clinical studies show that the natural form of GABA that is in Thorne's PharmaGABA can decrease the brain's stress-related beta waves and increase the production of its alpha-waves, creating a profound sense of physical relaxation while maintaining mental focus.* Other studies have shown reduced pupil diameter, heart rate, and two natural biomarkers of stress – salivary cortisol and chromogranin A – all signs of relaxation.* In addition, studies also indicate GABA can enhance sleep.* In a head-to-head, double-blind trial of natural PharmaGABA versus synthetic GABA, the synthetic GABA did not demonstrate these positive effects.* PharmaGABA-250 offers 250 mg of natural GABA per capsule, while PharmaGABA-100 offers 100 mg per capsule. Both are non-habit forming.

In a recent study of the effect of nutrient supplementation on muscle mass, 21 males, average age 39, who did not exercise regularly, were given 10 grams of whey protein or 10 grams of whey protein plus 100 mg of PharmaGABA daily for 12 weeks. Both groups participated in twice weekly 60-minute strength training sessions that consisted of leg presses, leg extensions, leg curls, chest presses, and pull-downs. Total body lean muscle mass increased significantly in the whey protein-plus-PharmaGABA group compared to the whey-only group.*

The natural GABA in Thorne's PharmaGABA suite is produced via a fermentation process that utilizes Lactobacillus hilgardii, the same bacteria that is used to ferment cabbage in the preparation of the traditional Korean dish known as kimchi.